Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis

Laura Dirkx; Sarah Hendrickx; Margot Merlot; Dimitri Bulté; Marick Starick; Jessy Elst; André Bafica; Didier G. Ebo; Louis Maes; Johan Van Weyenbergh; Guy Caljon

doi:10.1038/s42003-022-03591-7

Communications Biology (Jun 2022)

Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis

Laura Dirkx,
Sarah Hendrickx,
Margot Merlot,
Dimitri Bulté,
Marick Starick,
Jessy Elst,
André Bafica,
Didier G. Ebo,
Louis Maes,
Johan Van Weyenbergh,
Guy Caljon

Affiliations

Laura Dirkx: Laboratory of Microbiology, Parasitology, and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp
Sarah Hendrickx: Laboratory of Microbiology, Parasitology, and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp
Margot Merlot: Laboratory of Microbiology, Parasitology, and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp
Dimitri Bulté: Laboratory of Microbiology, Parasitology, and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp
Marick Starick: Clinical and Epidemiological Virology, Department of Microbiology, Immunology, and Transplantation, Rega Institute of Medical Research, KU Leuven
Jessy Elst: Department of Immunology—Allergology—Rheumatology, Faculty of Medicine and Health Science and the Infla-Med Centre of Excellence, University of Antwerp, Antwerp University Hospital
André Bafica: Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology Federal University of Santa Catarina
Didier G. Ebo: Department of Immunology—Allergology—Rheumatology, Faculty of Medicine and Health Science and the Infla-Med Centre of Excellence, University of Antwerp, Antwerp University Hospital
Louis Maes: Laboratory of Microbiology, Parasitology, and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp
Johan Van Weyenbergh: Clinical and Epidemiological Virology, Department of Microbiology, Immunology, and Transplantation, Rega Institute of Medical Research, KU Leuven
Guy Caljon: Laboratory of Microbiology, Parasitology, and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp

DOI: https://doi.org/10.1038/s42003-022-03591-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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Long-term hematopoietic stem cells may act as protective niches for the Leishmania parasite, potentially contributing to treatment failure in cases of visceral leishmaniasis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal