Nature Communications (Jun 2021)
Sam68 promotes hepatic gluconeogenesis via CRTC2
- Aijun Qiao,
- Junlan Zhou,
- Shiyue Xu,
- Wenxia Ma,
- Chan Boriboun,
- Teayoun Kim,
- Baolong Yan,
- Jianxin Deng,
- Liu Yang,
- Eric Zhang,
- Yuhua Song,
- Yongchao C. Ma,
- Stephane Richard,
- Chunxiang Zhang,
- Hongyu Qiu,
- Kirk M. Habegger,
- Jianyi Zhang,
- Gangjian Qin
Affiliations
- Aijun Qiao
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Junlan Zhou
- Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine
- Shiyue Xu
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Wenxia Ma
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Chan Boriboun
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Teayoun Kim
- Department of Medicine - Endocrinology, Diabetes & Metabolism, University of Alabama at Birmingham, School of Medicine
- Baolong Yan
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Jianxin Deng
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Liu Yang
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Eric Zhang
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Yuhua Song
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Yongchao C. Ma
- Departments of Pediatrics, Neurology and Physiology, Northwestern University Feinberg School of Medicine, Anne & Robert H. Lurie Children’s Hospital of Chicago
- Stephane Richard
- Lady Davis Institute for Medical Research, McGill University
- Chunxiang Zhang
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Hongyu Qiu
- Center for Molecular and Translational Medicine, Institute of Biomedical Science Georgia State University
- Kirk M. Habegger
- Department of Medicine - Endocrinology, Diabetes & Metabolism, University of Alabama at Birmingham, School of Medicine
- Jianyi Zhang
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Gangjian Qin
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- DOI
- https://doi.org/10.1038/s41467-021-23624-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Hepatic gluconeogenesis is important for glucose homeostasis and a therapeutic target for type 2 diabetes. Here, the authors show that the RNA-binding adaptor protein Sam68 promotes the expression level of gluconeogenic genes and increases blood glucose levels by stabilizing the transcriptional coactivator CRTC2, while hepatic Sam68 deletion alleviates hyperglycemia in mice.
