Nature Communications (Apr 2016)
Diverse human extracellular RNAs are widely detected in human plasma
- Jane E. Freedman,
- Mark Gerstein,
- Eric Mick,
- Joel Rozowsky,
- Daniel Levy,
- Robert Kitchen,
- Saumya Das,
- Ravi Shah,
- Kirsty Danielson,
- Lea Beaulieu,
- Fabio C. P. Navarro,
- Yaoyu Wang,
- Timur R. Galeev,
- Alex Holman,
- Raymond Y. Kwong,
- Venkatesh Murthy,
- Selim E. Tanriverdi,
- Milka Koupenova,
- Ekaterina Mikhalev,
- Kahraman Tanriverdi
Affiliations
- Jane E. Freedman
- Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School
- Mark Gerstein
- Yale University Medical School, Computational Biology and Bioinformatics Program
- Eric Mick
- Department of Quantitative Health Sciences, University of Massachusetts Medical School
- Joel Rozowsky
- Yale University Medical School, Computational Biology and Bioinformatics Program
- Daniel Levy
- The Framingham Heart Study
- Robert Kitchen
- Yale University Medical School, Computational Biology and Bioinformatics Program
- Saumya Das
- Cardiovascular Institute, Beth Israel Deaconess Medical Center
- Ravi Shah
- Cardiovascular Institute, Beth Israel Deaconess Medical Center
- Kirsty Danielson
- Cardiovascular Institute, Beth Israel Deaconess Medical Center
- Lea Beaulieu
- Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School
- Fabio C. P. Navarro
- Yale University Medical School, Computational Biology and Bioinformatics Program
- Yaoyu Wang
- Center for Cancer Computational Biology, Dana Farber Cancer Institute
- Timur R. Galeev
- Yale University Medical School, Computational Biology and Bioinformatics Program
- Alex Holman
- Center for Cancer Computational Biology, Dana Farber Cancer Institute
- Raymond Y. Kwong
- Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital
- Venkatesh Murthy
- University of Michigan
- Selim E. Tanriverdi
- Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School
- Milka Koupenova
- Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School
- Ekaterina Mikhalev
- Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School
- Kahraman Tanriverdi
- Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School
- DOI
- https://doi.org/10.1038/ncomms11106
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Extracellular miRNAs are present in a variety of bodily fluids. Here, Freedman et al. analysed plasma-derived RNA by RNA-seq from 40 people followed by targeted RT-qPCR in an additional 2,763 people, and report over 1,000 extracellular RNAs including microRNAs, piwi-interacting RNA and small nucleolar RNAs.
