Dynamics of Regenerative Processes in Patients with Trophic Ulcers against the Background of Chronic Venous Hemodynamic Disturbances Using Therapy with Polydesoxyrinobonucleotides

Abstract

The aim of this study was to analyze the healing of trophic ulcers (TUs) of the skin against the background of chronic venous insufficiency (CVI) after applying PDRN-therapy in a complex of therapeutic measures. Materials and Methods: The study included 19 patients with TUs of various sizes and shapes (from 4 to 12 cm2) in the lower extremities with average duration from 4 weeks to 12 months, against the background of CVI. Patients were divided into two groups. Group 1 included 9 patients who received complex treatment along with using desoxyribonucleotide polymers (PDRN-therapy) according to the proposed methodology. Group 2 included 10 patients treated according to standard treatment of TUs. The area of wound defects was determined using the LesionMeter program. Skin thermometry was carried out using a B.Well WF-5000 medical infrared non-contact thermometer. Results: We found that in patients of Group 1, who received PDRN-therapy in addition to standard treatment, by Day 20 there was a reduction in the TU area to 51.06±0.1% of the initial size; in patients of Group 2, who received only standard treatment, the TU area was 85.56±0.1% of the initial size. The temperature in the center of the ulcer and in its periphery increased in patients of Group 1 compared to patients of Group 2 by 2.79% and 2.74%, respectively, indicating a better blood supply to the skin defect, possibly due to more active angiogenesis Conclusion: The use of PDRN-therapy in the complex treatment of TUs on the background of CVI is clinically effective. The applied method contributed to accelerating the repair processes of the skin defect and improving vascularization, which reduced the healing time of trophic ulcers.

Keywords

• polydesoxyribonucleotides
• trophic ulcer
• • planimetry
• thermometry