Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma

Joanna Radzikowska; Antoni Krzeski; Anna M. Czarnecka; Teresa Klepacka; Magdalena Rychlowska-Pruszynska; Anna Raciborska; Bozenna Dembowska-Baginska; Maciej Pronicki; Andrzej Kukwa; Janusz Sierdzinski; Wojciech Kukwa

doi:10.3390/jcm10030512

Journal of Clinical Medicine (Feb 2021)

Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma

Joanna Radzikowska,
Antoni Krzeski,
Anna M. Czarnecka,
Teresa Klepacka,
Magdalena Rychlowska-Pruszynska,
Anna Raciborska,
Bozenna Dembowska-Baginska,
Maciej Pronicki,
Andrzej Kukwa,
Janusz Sierdzinski,
Wojciech Kukwa

Affiliations

Joanna Radzikowska: Department of Otorhinolaryngology, Faculty of Dental Medicine, Medical University of Warsaw, 19/25 Stepinska St., 00-739 Warsaw, Poland
Antoni Krzeski: Department of Otorhinolaryngology, Faculty of Dental Medicine, Medical University of Warsaw, 19/25 Stepinska St., 00-739 Warsaw, Poland
Anna M. Czarnecka: Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute—Oncology Center, 5 Roentgena St., 02-781 Warsaw, Poland
Teresa Klepacka: Department of Pathology, Institute of Mother and Child, 17a Kasprzaka St., 01-211 Warsaw, Poland
Magdalena Rychlowska-Pruszynska: Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, 17a Kasprzaka St., 01-211 Warsaw, Poland
Anna Raciborska: Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, 17a Kasprzaka St., 01-211 Warsaw, Poland
Bozenna Dembowska-Baginska: Department of Pediatric Oncology, The Children’s Memorial Health Institute, 20 Dzieci Polskich St., 04-730 Warsaw, Poland
Maciej Pronicki: Department of Pathology, The Children’s Memorial Health Institute, 20 Dzieci Polskich St., 04-730 Warsaw, Poland
Andrzej Kukwa: Department of Otolaryngology and Head and Neck Diseases, School of Medicine, University of Warmia and Mazury, 30 Warszawska St., 10-082 Olsztyn, Poland
Janusz Sierdzinski: Department of Medical Informatics and Telemedicine, Medical University of Warsaw, 14/16 Litewska St., 00-581 Warsaw, Poland
Wojciech Kukwa: Department of Otorhinolaryngology, Faculty of Dental Medicine, Medical University of Warsaw, 19/25 Stepinska St., 00-739 Warsaw, Poland

DOI: https://doi.org/10.3390/jcm10030512
Journal volume & issue: Vol. 10, no. 3
p. 512

Abstract

Read online

(1) Background: The study proposed to analyze microvessel density (MVD) in rhabdomyosarcoma (RMS) based on the expression of angiogenesis markers and define its prognostic role in this group of patients. (2) Methods: The study included forty-nine pediatric patients diagnosed with RMS. Tumor tissue expression of CD31, CD34, and CD105 was analyzed. MVD was calculated and correlated with clinical RMS prognostic parameters. (3) Results: CD31, CD34, and CD105 are expressed in all RMS cases. MVD/CD105 was significantly higher in the RMS group than in the control group. The mean and median values of MVD/CD105 in RMS were lower than MVD/CD31 and MVD/CD34. MVD/CD105 was significantly higher in patients with alveolar RMS and those with metastatic disease. Patients with higher levels of MVD/CD105 had a higher risk of death (HR = 1.009). (4) Conclusion: CD105 is a relevant angiogenesis marker in pediatric RMS, and MVD/CD105 is an independent risk factor of short overall survival in children with RMS.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

About the journal

Abstract

Keywords