Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis

Mohammed Kanan; Mohammed Naffaa; Ahmed Alanazi; Faiz Nasser; Ahad Amer Alsaiari; Mazen Almehmadi; Ali Assiry; Hisham Muzafar; Hejab Katam; Abdullah Arar; Syed Mohammed Basheeruddin Asdaq; Abida; Mohd Imran; Tafadzwa Dzinamarira

Journal of Infection and Public Health (Apr 2024)

Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis

Mohammed Kanan,
Mohammed Naffaa,
Ahmed Alanazi,
Faiz Nasser,
Ahad Amer Alsaiari,
Mazen Almehmadi,
Ali Assiry,
Hisham Muzafar,
Hejab Katam,
Abdullah Arar,
Syed Mohammed Basheeruddin Asdaq,
Abida,
Mohd Imran,
Tafadzwa Dzinamarira

Affiliations

Mohammed Kanan: Department of Clinical Pharmacy, King Fahad Medical City, Riyadh 12211, Saudi Arabia
Mohammed Naffaa: Department of Forensic Toxicology, Poison Center, Arar, Northern Borders Region 73241, Saudi Arabia
Ahmed Alanazi: Poison Control and Forensic Chemistry Center, Arar, Northern Borders Region 73551, Saudi Arabia
Faiz Nasser: Department of Forensic Toxicology, Poison Center, Arar, Northern Borders Region 75861, Saudi Arabia
Ahad Amer Alsaiari: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Mazen Almehmadi: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Ali Assiry: Department of Medical Supply, Mohayil Hospital, Health Affairs of Aseer, Abha 63711, Saudi Arabia
Hisham Muzafar: Department of Pharmacy, Jazan University Hospital, Jazan University, Jazan 82723, Saudi Arabia
Hejab Katam: Department of Radiology, Extended Care Hospital, Arar, Northern Borders Region 73551, Saudi Arabia
Abdullah Arar: Public Health Department, Northern Border Regional Lab & Blood Bank, Arar, Northern Borders Region 73241, Saudi Arabia
Syed Mohammed Basheeruddin Asdaq: Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, 13713 Riyadh, Saudi Arabia
Abida: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia
Mohd Imran: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia; Corresponding author.
Tafadzwa Dzinamarira: School of Health Systems and Public Health, University of Pretoria, Pretoria 0002, South Africa; ICAP, Columbia University, P.O. Box 28, Harare, Zimbabwe; Corresponding author at: School of Health Systems and Public Health, University of Pretoria, Pretoria 0002, South Africa.

Journal volume & issue: Vol. 17, no. 4
pp. 579 – 587

Abstract

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Dengue hemorrhagic fever (DHF) is a severe condition resulting from the dengue virus, with four serotypes known as DEN-1, DEN-2, DEN-3, and DEN-4. Genetic variations play a crucial role in influencing susceptibility to DHF. Therefore, this investigation conducted a meta-analysis to uncover genetic changes that might have remained undetected in individual studies due to small sample sizes or methodological differences. Among 2212 initially identified studies, 23 were deemed suitable for analysis based on PRISMA guidelines. Toll-like receptors (TLR) and CD209 showed significant association with DHF (odds ratios: TLR=0.56, CD209 =0.55), indicating protective effects. However, tumor necrosis factor (TNF) and human leukocyte antigen (HLA) did not exhibit a statistically significant relationship with DHF. This study emphasizes the relevance of TLR and CD209 in DHF susceptibility and resistance across diverse geographical locations.

Published in Journal of Infection and Public Health

ISSN: 1876-0341 (Print); 1876-035X (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/journal-of-infection-and-public-health

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