Infection and Drug Resistance (Dec 2021)

High Prevalence of Klebsiella pneumoniae Infections in AnHui Province: Clinical Characteristic and Antimicrobial Resistance

  • Su C,
  • Wu T,
  • Meng B,
  • Yue C,
  • Sun Y,
  • He L,
  • Bian T,
  • Liu Y,
  • Huang Y,
  • Lan Y,
  • Li J

Journal volume & issue
Vol. Volume 14
pp. 5069 – 5078

Abstract

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Cong Su,1,* Ting Wu,2,* Bao Meng,2 Chengcheng Yue,2 Yating Sun,2 Lingling He,2 Tingting Bian,2 Yanyan Liu,3,4 Ying Huang,5 Yanhu Lan,4 Jiabin Li2– 4,6 1Department of Infection Management, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 3Anhui Center for Surveillance of Bacterial Resistance, Hefei, People’s Republic of China; 4Institute of Bacterial Resistance, Anhui Medical University, Hefei, People’s Republic of China; 5Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 6Department of Infectious Diseases, The Chaohu Hospital of Anhui Medical University, Hefei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiabin LiDepartment of Infectious Diseases, The First Affiliated Hospital and the Chaohu Hospital of Anhui Medical University, Jixi Road 218, Hefei, 230022, People’s Republic of ChinaEmail [email protected] LanInstitute of Bacterial Resistance, Anhui Medical University, Jixi Road 218, Hefei, 230022, People’s Republic of ChinaEmail [email protected]: Klebsiella pneumoniae (K. pneumoniae) causes community-acquired and hospital-acquired pneumonia. The mortality rates of invasive infections caused by hypervirulent K. pneumoniae (HvKP) are extremely high. However, the microbiological characteristics and clinical manifestations of K. pneumoniae in AnHui province still remain unclear.Purpose: To show the high prevalence of HvKP infections regarding clinical characteristics and antimicrobial resistance in Anhui province.Patients and Methods: A retrospective analysis was conducted to study the clinical data of 115 strains of K. pneumoniae from July 2019 to March 2020 in The First Affiliated Hospital of AnHui Medical University. The virulence genes, capsular types, carbapenemase genes, and molecular subtypes of these hypervirulent isolates were detected.Results: Overall, 59.1% (68/115) cases were HvKP infections, mainly from the department of intensive care unit (ICU, n=14, 20.6%) and the department of respiratory and critical care (n=13, 19.1%). K2 was the most prevalent capsular serotype (n=26), followed by K1 (n=21). The results of MLST identification of 68 strains showed that ST23 (n=15, 22.1%) was the most common type of ST, followed by ST11 and ST65 (n=12, 17.6%), ST86 (n=9, 13.2%), and ST412 (n=6, 8.8%). Among 68 hvKP strains, 12 isolates were carbapenem resistant, and all except two harboured KPC.Conclusion: The high incidence of carbapenemase producing HvKP in the Anhui province, especially the higher mortality of HvKP, should be paid more attention. Meanwhile, epidemiological surveillance and clinical treatment strategies should be continuously determined and implemented.Keywords: Klebsiella pneumoniae, virulence genes, capsular types, antimicrobial resistance

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