Journal of Pharmacopuncture (Sep 2010)

Beneficial Effect of Paljeong-san Pharmacopuncture Treatment Combined with Peritoneal Injection on Glycerol-Induced Acute Renal Failure in Rabbits

  • Chi-Yeon Lim,
  • Min-Ho Kim,
  • Geum-San Lee,
  • Hyung-Woo Kim,
  • Bu-Yeo Kim,
  • Yeo-Choong Yun,
  • Su-In Cho

DOI
https://doi.org/10.3831/KPI.2010.13.3.073
Journal volume & issue
Vol. 13, no. 3
pp. 73 – 80

Abstract

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Purpose: The present study was carried out to determine if Paljeong-san extract (PJS) treatment exerts beneficial effect against the glycerol-induced acute renal failure in rabbits. Material and Method: PJS was selected in the basis of invigorating kidney which can eliminate pathogens. Rabbits were treated with PJS pharmacopuncture on Shin-shu (BL23) point for 5 days right after the injection of 50% concentration of glycerol (5㎖/㎏ body weight). Results and Conclusions: Glycerol injection caused an increase in serum creatinine and BUN level and urine glucose secretion, which were accompanied by a reduction in GFR. PJS Pharmacopuncture treatment combined with peritoneal injection showed beneficial effect on glycerol-induced acute renal failure by inhibition of serum creatinine increase and GFR decrease.

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