NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes

Abstract

Astrocytes maintain central nerve system homeostasis and are relatively resistant to cell death. Dysfunction of cell death mechanisms may underlie glioblastoma genesis and resistance to cancer therapy; therefore more detailed understanding of astrocytic death modalities is needed in order to design effective therapy. The purpose of this study was to determine the effect of VAS2870, a pan-NADPH oxidase inhibitor, on staurosporine-induced cell death in astrocytes.

Keywords

• astrocytes
• vas2870
• mitochondrial potential
• atp
• reactive oxygen species
• cell death