The first mitotic division of human embryos is highly error prone

Cerys E. Currie; Emma Ford; Lucy Benham Whyte; Deborah M. Taylor; Bettina P. Mihalas; Muriel Erent; Adele L. Marston; Geraldine M. Hartshorne; Andrew D. McAinsh

doi:10.1038/s41467-022-34294-6

Nature Communications (Nov 2022)

The first mitotic division of human embryos is highly error prone

Cerys E. Currie,
Emma Ford,
Lucy Benham Whyte,
Deborah M. Taylor,
Bettina P. Mihalas,
Muriel Erent,
Adele L. Marston,
Geraldine M. Hartshorne,
Andrew D. McAinsh

Affiliations

Cerys E. Currie: Division of Biomedical Sciences, Warwick Medical School, University of Warwick
Emma Ford: Division of Biomedical Sciences, Warwick Medical School, University of Warwick
Lucy Benham Whyte: University Hospitals Coventry and Warwickshire NHS Trust
Deborah M. Taylor: University Hospitals Coventry and Warwickshire NHS Trust
Bettina P. Mihalas: Wellcome Centre for Cell Biology, University of Edinburgh
Muriel Erent: Division of Biomedical Sciences, Warwick Medical School, University of Warwick
Adele L. Marston: Wellcome Centre for Cell Biology, University of Edinburgh
Geraldine M. Hartshorne: Division of Biomedical Sciences, Warwick Medical School, University of Warwick
Andrew D. McAinsh: Division of Biomedical Sciences, Warwick Medical School, University of Warwick

DOI: https://doi.org/10.1038/s41467-022-34294-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Human beings arise from serial mitotic divisions of a single fertilised egg. Here through live cell imaging of fertilized embryos the authors show that the first mitotic division is error prone and can contribute to preimplantation mosaicism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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