Nature Communications (Aug 2019)
Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets
- Jeong-Eun Kwak,
- Young-Il Kim,
- Su-Jin Park,
- Min-Ah Yu,
- Hyeok-Il Kwon,
- Sukyeong Eo,
- Tae-Shin Kim,
- Joon Seok,
- Won-Suk Choi,
- Ju Hwan Jeong,
- Hyojin Lee,
- Youngran Cho,
- Jin Ah Kwon,
- Moonsup Jeong,
- Joel N. Maslow,
- Yong-Eun Kim,
- Haili Jeon,
- Kee K. Kim,
- Eui-Cheol Shin,
- Min-Suk Song,
- Jae U. Jung,
- Young Ki Choi,
- Su-Hyung Park
Affiliations
- Jeong-Eun Kwak
- Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology
- Young-Il Kim
- Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University
- Su-Jin Park
- Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University
- Min-Ah Yu
- Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University
- Hyeok-Il Kwon
- Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University
- Sukyeong Eo
- Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology
- Tae-Shin Kim
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
- Joon Seok
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
- Won-Suk Choi
- Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University
- Ju Hwan Jeong
- Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University
- Hyojin Lee
- GeneOne Life Science, Inc.
- Youngran Cho
- GeneOne Life Science, Inc.
- Jin Ah Kwon
- GeneOne Life Science, Inc.
- Moonsup Jeong
- GeneOne Life Science, Inc.
- Joel N. Maslow
- GeneOne Life Science, Inc.
- Yong-Eun Kim
- Department of Biochemistry, Chungnam National University
- Haili Jeon
- Department of Biochemistry, Chungnam National University
- Kee K. Kim
- Department of Biochemistry, Chungnam National University
- Eui-Cheol Shin
- Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology
- Min-Suk Song
- Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University
- Jae U. Jung
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Young Ki Choi
- Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University
- Su-Hyung Park
- Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-019-11815-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus with no specific treatment or vaccine available. Here, the authors develop a DNA vaccine for SFTSV that is protective against lethal challenge in ferrets and show that anti-envelope antibodies are important for protection.
