Nature Communications (Aug 2019)

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

  • Pooja Jadiya,
  • Devin W. Kolmetzky,
  • Dhanendra Tomar,
  • Antonio Di Meco,
  • Alyssa A. Lombardi,
  • Jonathan P. Lambert,
  • Timothy S. Luongo,
  • Marthe H. Ludtmann,
  • Domenico Praticò,
  • John W. Elrod

DOI
https://doi.org/10.1038/s41467-019-11813-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2 + exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progression.