Title: Effect of six-week high intensity interval training under simulated microgravity condition on morphology of radial nerve myelin sheet in male rats

Abstract

The purpose of this study was to investigate the effect of six weeks of HIIT under simulated microgravity condition on morphological changes of radial nerve myelin sheath in male rats. In present study, 24 male wistar rats were randomly selected and divided into four groups including: TS(training during suspension:n=6), CS(suspension:n=6), T(training:n=6), C(control:n=6). The training groups run on treadmill for six weeks (five days in week). 24 hours after the last training session, the animals were prepared for tissue samples. At the end of the experiment, changes in myelin sheath were measured by Luxol fast blue. Our results showed that the percentage of changes in myelin sheath in HIIT group under simulate microgravity (p≤0.001) was highest than other groups, significantly (30/27+5/27). Based on the results, HIIT under simulated microgravity condition affected on changes in myelin sheath, Therefore, it seems that can play an effective role in improvement of the clinical status of neurological patients and decrease side effects in Astronauts.

Keywords

• simulated microgravity
• radial nerve
• myelin sheath
• peripheral nervous system
• high intensity interval training