Communications Biology (Apr 2021)

Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival

  • Megumi Nishinaga,
  • Hiroshi Sugimoto,
  • Yudai Nishitani,
  • Seina Nagai,
  • Satoru Nagatoishi,
  • Norifumi Muraki,
  • Takehiko Tosha,
  • Kouhei Tsumoto,
  • Shigetoshi Aono,
  • Yoshitsugu Shiro,
  • Hitomi Sawai

DOI
https://doi.org/10.1038/s42003-021-01987-5
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 12

Abstract

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Nishinaga et al. present structural characterization of the transcription regulator PefR from S. agalactiae in different states (apo-, DNAbound, heme-bound, CO-heme-bound and CN-heme-bound-PefRs). Structural comparison revealed that unique heme coordination controls structural rearrangement for the survival of the neonatal infection-causing hemolytic bacteria.