Molecules (Feb 2019)

New Iridoid Derivatives from the Fruits of <i>Cornus officinalis</i> and Their Neuroprotective Activities

  • Lin-lin Ji,
  • Xin Wang,
  • Jin-jie Li,
  • Xiang-jian Zhong,
  • Bo Zhang,
  • Jing Juan,
  • Xiao-ya Shang

DOI
https://doi.org/10.3390/molecules24030625
Journal volume & issue
Vol. 24, no. 3
p. 625

Abstract

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Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.

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