Diabetes, Metabolic Syndrome and Obesity (Jul 2024)

Association Between Visceral Obesity and Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Retrospective Study

  • Shang C,
  • Yuan M,
  • Wang Y,
  • Wang Y,
  • Bao W,
  • Zeng S,
  • Zhang D,
  • Liu P,
  • Sun L

Journal volume & issue
Vol. Volume 17
pp. 2869 – 2880

Abstract

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Chang Shang,1,* Mengfei Yuan,1,* Yue Wang,1,* Yahui Wang,2 Wujisiguleng Bao,2 Shuanghui Zeng,2 Dandan Zhang,2 Ping Liu,2,3 Luying Sun2,3 1Department of Nephropathy and Endocrine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Fangshan Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3Integrated Chinese and Western Medicine Metabolic Disease Research Center, Fangshan Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Luying Sun; Ping Liu, Fangshan Hospital, Beijing University of Chinese Medicine, No. 4, Health Care Road, Chengguan Street, Fangshan District, Beijing, 102499, People’s Republic of China, Email [email protected]; [email protected]: To investigate the association between visceral obesity and glycemic control in patients with type 2 diabetes mellitus.Patients and Methods: A retrospective analysis involved 714 patients diagnosed with type 2 diabetes mellitus from the National Metabolic Management Center from November 2021 to February 2024. Medical data included sociodemographic data, lifestyle behaviors, and anthropometric and biochemical measurements. Multivariate logistic regression analysis was used to analyze their associations.Results: Among the patients, 251 (35.2%) achieved good glycemic control (HbA1c < 7.0%). On univariate analysis, higher diastolic blood pressure, longer duration of type 2 diabetes mellitus, tobacco smoking, alcohol drinking, insulin treatment, higher levels of fasting plasma glucose, homeostasis model assessment of insulin resistance, triglyceride, total cholesterol, and low-density lipoprotein cholesterol, visceral obesity (visceral fat area ≥ 100cm2) and diabetic peripheral neuropathy were all positively correlated with poor glycemic control; female, older age, higher levels of C peptide and serum uric acid were inversely associated with poor glycemic control (all P < 0.05). On multivariate logistic regression analysis, the results suggested that higher diastolic blood pressure [OR: 1.021, 95% CI (1.002, 1.040), P = 0.030], insulin treatment [currently used: OR = 2.156, 95% CI (1.249, 3.724), P = 0.006], higher level of fasting plasma glucose [OR: 1.819, 95% CI (1.598, 2.069), P < 0.001], and visceral obesity [OR: 1.876, 95% CI (1.158, 3.038), P = 0.011] were risk factors for poor glycemic control.Conclusion: This study indicated that visceral obesity (visceral fat area ≥ 100cm2) is positively associated with poor glycemic control, and serves as an independent risk factor for poor glycemic control (HbA1c ≥ 7.0%) in patients with type 2 diabetes mellitus. Screening for visceral obesity should be emphasized, and targeted interventions should be taken to improve glycemic control in patients with type 2 diabetes mellitus.Keywords: type 2 diabetes mellitus, glycemic control, influencing factors, visceral obesity, visceral fat area

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