HISTOPATHOLOGICAL CHANGES IN HEALING OF CUTANEOUS WOUNDS TREATED WITH BOVINE COLLAGEN AND BOVINE COLLAGENALGINATE DRESSING IN DOGS

Abstract

Twelve dogs with full thickness cutaneous wounds such as dog bitten wounds, traumatic accident wounds and chronic wounds were selected and randomly divided into two groups. In Group I, a pre-sterilized bovine collagen-alginate sheet and in Group II, a presterilized bovine collagen sheet were applied as wound dressing. Re-application of dressing was continued at 48 hours intervals for a two more timesand afterwards weekly bandaging was followed. The animals were observed for a period of 28 days and a cutaneous punch biopsy from the mid-portion of healing wound was taken on day 28 for histopathological examination to evaluate the progress of wound healing. The results of the study revealed that both bovine collagen and bovine collagenalginate had good graft acceptance, with no adverse reactions and helped in the augmentation of wound healing process.

Keywords

• bovine collagen
• collagen-alginate
• wound healing
• dogs