mSystems
(Oct 2021)
Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies
Victoria M. Anderson,
Karen L. Wendt,
Fares Z. Najar,
Laura-Isobel McCall,
Robert H. Cichewicz
Affiliations
Victoria M. Anderson
Natural Products Discovery Group, University of Oklahoma, Norman, Oklahoma, USA
Karen L. Wendt
Natural Products Discovery Group, University of Oklahoma, Norman, Oklahoma, USA
Fares Z. Najar
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA
Laura-Isobel McCall
ORCiD Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA
Robert H. Cichewicz
ORCiD Natural Products Discovery Group, University of Oklahoma, Norman, Oklahoma, USA
DOI
https://doi.org/10.1128/mSystems.00644-21
Journal volume & issue
Vol. 6,
no. 5
Abstract
Read online
Natural product drug discovery efforts rely on libraries of organisms to provide access to diverse pools of compounds. Actionable strategies to rationally maximize chemical diversity, rather than relying on serendipity, can add value to such efforts.
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