The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study
Li Kong,
Yao Zhang,
Xu-ming Wu,
Xiao-xiao Wang,
Hai-su Wu,
Shuai-biao Li,
Min-yi Chu,
Yi Wang,
Simon S. Y. Lui,
Qin-yu Lv,
Zheng-hui Yi,
Raymond C. K. Chan
Affiliations
Li Kong
Department of Psychology, Shanghai Normal University
Yao Zhang
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine
Xu-ming Wu
Nantong Fourth People’s Hospital
Xiao-xiao Wang
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine
Hai-su Wu
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine
Shuai-biao Li
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine
Min-yi Chu
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine
Yi Wang
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Simon S. Y. Lui
Department of Psychiatry, School of Clinical Medicine, The University of Hong Kong
Qin-yu Lv
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine
Zheng-hui Yi
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine
Raymond C. K. Chan
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine
Abstract Previous studies on putative neural mechanisms of negative symptoms in schizophrenia mainly used single modal imaging data, and seldom utilized schizophrenia patients with prominent negative symptoms (PNS).This study adopted the multimodal fusion method and recruited a homogeneous sample with PNS. We aimed to identify negative symptoms-related structural and functional neural correlates of schizophrenia. Structural magnetic resonance imaging (sMRI) and resting-state functional MRI (rs-fMRI) were performed in 31 schizophrenia patients with PNS and 33 demographically matched healthy controls.Compared to healthy controls, schizophrenia patients with PNS exhibited significantly altered functional activations in the default mode network (DMN) and had structural gray matter volume (GMV) alterations in the cerebello-thalamo-cortical network. Correlational analyses showed that negative symptoms severity was significantly correlated with the cerebello-thalamo-cortical structural network, but not with the DMN network in schizophrenia patients with PNS.Our findings highlight the important role of the cerebello-thalamo-cortical structural network underpinning the neuropathology of negative symptoms in schizophrenia. Future research should recruit a large sample and schizophrenia patients without PNS, and apply adjustments for multiple comparison, to verify our preliminary findings.
