BMJ Open (Nov 2024)
Acceptability, barriers and facilitators of using dried blood spots-point-of-care testing for sickle cell disease in Africa: an implementation science protocol for a multinational qualitative study
- Andre Pascal Kengne,
- Leon Tshilolo,
- Grace Ndeezi,
- Nicola Mulder,
- Moses Joloba,
- Victoria Nembaware,
- Nchangwi Syntia Munung,
- Vivian Paintsil,
- Emmanuel Peprah,
- Fred Stephen Sarfo,
- Deogratias Munube,
- Collen Masimirembwa,
- Ambroise Wonkam,
- Daniel Ansong,
- Kwaku Ohene-Frempong,
- Ezekiel Mupere,
- Sarah Kiguli,
- Julie Makani,
- Josephine Mgaya,
- Siana Nkya,
- Fred Semitala,
- Raphael Zozimus Sangeda,
- Emmanuel Balandya,
- Anazoeze Madu,
- Catherine Chunda-Liyoka,
- Yeya Dit Sadio Sarro,
- Daudi Jjingo,
- Obiageli Eunice Nnodu,
- Lulu Chirande,
- Boubacari Ali Touré,
- Aldiouma Guindo,
- Patience Kuona,
- Kevin Esoh,
- Mario Jonas,
- Maxwell Nwegbu,
- Upendo Masamu,
- Jack Morrice,
- Patrick Ohiani Moru,
- Valentina Ngo Bitoungui,
- Hans Ackerman,
- Alex Osei Akoto,
- Emmanuela Ambrose,
- Evans Amuzu,
- Samuel Asala,
- Biobele Brown,
- Mmbando Bruno,
- Daima Bukini,
- Pamela Gorejena,
- Abdul Aziz Hassan,
- Justin Hokororo,
- Jade Hotchkiss,
- Abdoul Malik Idris,
- Hezekiah Isa,
- Agnes Jonathan,
- Gwendoline Q. Kandawasvika,
- Daniel Kandonga,
- Ibrahima Keita,
- Sekou Kene,
- Frank Makundi,
- Janeth Manongi,
- Hamakwa Mantina,
- Jason Maro,
- Irene Kida Minja,
- Khuthala Mnika,
- Takudzwa Mtisi,
- Wilson Mupfururirwa,
- Ritah Mutagonda,
- Ruth Namazzi,
- Solomon Ofori-Aquah,
- Emmanuel Okocha,
- Fumni Olopade,
- Jesca Ondego,
- Chandré Oosterwyk-Liu,
- Nash Oyekanmi,
- Stella Paul,
- Cynthia Phiri,
- Paschal Ruggajo,
- Parker Ruhl,
- Ian Machingura Ruredzo,
- Pauline Sambo,
- Sawabati Shabani,
- Florence Urio,
- Robert Opoka
Affiliations
- Andre Pascal Kengne
- Leon Tshilolo
- 15 Institut de Recherche Biomédicale, Centre Hospitalier Mère-Enfant, Université de Mbuji-Mayi, Mbuji-Mayi, Congo (the Democratic Republic of the)
- Grace Ndeezi
- Nicola Mulder
- Moses Joloba
- Victoria Nembaware
- 2 Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
- Nchangwi Syntia Munung
- 2 Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
- Vivian Paintsil
- Emmanuel Peprah
- 16 School of Global Public Health, New York University, New York, New York, USA
- Fred Stephen Sarfo
- 8 Neurology Unit, Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
- Deogratias Munube
- Collen Masimirembwa
- Ambroise Wonkam
- 2 Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
- Daniel Ansong
- Kwaku Ohene-Frempong
- Ezekiel Mupere
- Sarah Kiguli
- 7 Department of Paediatrics and Child Health, Makerere University Faculty of Medicine, Kampala, Uganda
- Julie Makani
- 13 The Sickle Cell Programme, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, United Republic of
- Josephine Mgaya
- Siana Nkya
- 13 The Sickle Cell Programme, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, United Republic of
- Fred Semitala
- Raphael Zozimus Sangeda
- Emmanuel Balandya
- 10 Department of Physiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, United Republic of
- Anazoeze Madu
- Catherine Chunda-Liyoka
- 4 Ministry of Health, Lusaka, Zambia
- Yeya Dit Sadio Sarro
- Daudi Jjingo
- Obiageli Eunice Nnodu
- 1 Center of Excellence for Sickle Cell Disease Research and Training (CESRTA), University of Abuja, Abuja, Nigeria
- Lulu Chirande
- 3 Department of Paediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
- Boubacari Ali Touré
- 9 Centre de Recherche et Lutte contre la Drépanocytose (CRLD), Bamako, Mali
- Aldiouma Guindo
- 9 Centre de Recherche et Lutte contre la Drépanocytose (CRLD), Bamako, Mali
- Patience Kuona
- 11 Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe
- Kevin Esoh
- 2 Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
- Mario Jonas
- 2 Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
- Maxwell Nwegbu
- 1 Center of Excellence for Sickle Cell Disease Research and Training (CESRTA), University of Abuja, Abuja, Nigeria
- Upendo Masamu
- 13 The Sickle Cell Programme, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, United Republic of
- Jack Morrice
- 2 Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
- Patrick Ohiani Moru
- 1 Center of Excellence for Sickle Cell Disease Research and Training (CESRTA), University of Abuja, Abuja, Nigeria
- Valentina Ngo Bitoungui
- 14 Faculty of Medicine and Pharmaceutical Science, University of Dschang, Dschang, Cameroon
- Hans Ackerman
- Alex Osei Akoto
- Emmanuela Ambrose
- Evans Amuzu
- Samuel Asala
- Biobele Brown
- Mmbando Bruno
- Daima Bukini
- Pamela Gorejena
- Abdul Aziz Hassan
- Justin Hokororo
- Jade Hotchkiss
- Abdoul Malik Idris
- Hezekiah Isa
- Agnes Jonathan
- Gwendoline Q. Kandawasvika
- Daniel Kandonga
- Ibrahima Keita
- Sekou Kene
- Frank Makundi
- Janeth Manongi
- Hamakwa Mantina
- Jason Maro
- Irene Kida Minja
- Khuthala Mnika
- Takudzwa Mtisi
- Wilson Mupfururirwa
- Ritah Mutagonda
- Ruth Namazzi
- Solomon Ofori-Aquah
- Emmanuel Okocha
- Fumni Olopade
- Jesca Ondego
- Chandré Oosterwyk-Liu
- Nash Oyekanmi
- Stella Paul
- Cynthia Phiri
- Paschal Ruggajo
- Parker Ruhl
- Ian Machingura Ruredzo
- Pauline Sambo
- Sawabati Shabani
- Florence Urio
- Robert Opoka
- DOI
- https://doi.org/10.1136/bmjopen-2024-089056
- Journal volume & issue
-
Vol. 14,
no. 11
Abstract
Background Sickle cell disease (SCD) is a prevalent inherited blood disorder. Globally, approximately 515 000 babies are born with SCD annually, with 75% of these births occurring in Africa. Integrating newborn screening (NBS) for SCD into primary healthcare structures, such as immunisation programmes, holds significant promise, with dried blood spots (DBS)-point-of-care technologies (POCT) like HaemoTypeSC offering cost-effective screening solutions. However, scaling up DBS-POCT for NBS of SCD in Africa remains challenging.Objective This study aims to explore individual, organisational and external factors that may influence the reliability, feasibility, acceptability, adoption and sustainability of using DBS-POCT with HaemoTypeSC for NBS of SCD at primary healthcare centres in African countries.Method This qualitative study will be conducted in seven African countries that are part of the SickleInAfrica consortium sites. The study design is informed by the Consolidated Framework for Implementation Research (CFIR) and the Implementation Outcome Model. Participants will be mothers whose babies have been diagnosed with SCD, healthcare professionals and policy-makers. In-depth interviews and focus group discussions will be used for data collection. Data analysis will be through thematic analysis.Ethics and dissemination Research ethics approvals have been obtained from the seven countries. Written informed consent will be obtained from all participants. The study results will be disseminated in peer-reviewed scientific journals, scientific conferences, reports to national ministries of public health and webinars.
