Ethnicity and prostate cancer in Southern Nigeria: A preliminary report

Nigerian Journal of Surgery. 2015;21(2):96-101 DOI 10.4103/1117-6806.162590

 

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Journal Title: Nigerian Journal of Surgery

ISSN: 1117-6806 (Print); 2278-7100 (Online)

Publisher: Wolters Kluwer Medknow Publications

Society/Institution: Nigerian Surgical Research Society, Association of Surgeons of Nigeria

LCC Subject Category: Medicine: Surgery

Country of publisher: India

Language of fulltext: English

Full-text formats available: HTML

 

AUTHORS

Monday K Sapira
Ndubuisi Eke
Alexander ME Nwofor

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 37 weeks

 

Abstract | Full Text

Introduction: The natural history of prostate cancer varies among patients. The aim of this study is to detect any variations in clinical and pathological characteristics of the tumor in patients from different ethnic groups in Southern Nigeria. Patients and Methods: Consecutive patients who presented with features of prostatic diseases at the Urology Units of University of Port Harcourt Teaching Hospital, Port Harcourt and Nnamdi Azikiwe University Teaching Hospital, Nnewi, were evaluated prospectively with history, physical examination, and relevant investigations using a proforma. Data obtained were collated and analyzed statistically using the Chi-square test and Microsoft Excel. Results: Of 187 patients studied, 169 were analyzed. Eighty-six were Ibos, 31 Ijaws, 25 Ikwerres, and 12 Ogonis. Two were from each Etche, Urhobo, Opobo, and Effik; 4 from Andoni, and 3 Ibibio. Fifty-seven (66.3%) Ibos presented with the disease at higher ages (70–80 years) than 19 (61.3%) Ijaws and 11 (91.7%) Ogonis. These age differences were statistically significant with 95% and 99.9% confidence, respectively. All cases were adenocarcinomas. Clinical features, pattern of serum prostate-specific antigen levels, grades of the tumors, tumor metastases, and complications were similar for all ethnic groups. Although more Ibos had tumors with relatively more aggressive metastatic features, there was no statistical significance. Conclusion: Clinical and pathological features of adenocarcinoma of the prostate in Ibos, Ikwerres, Ijaws, and Ogonis were found to be similar. However, Ibos presented with the disease at older ages than Ijaws and Ogonis.