Histogenesis and Histomorphometric Study of Human Foetal Cerebellar Cortex

Abstract

Background: It has been seen that there is progressive loss of Purkinje cells in various genetic conditions like ataxia telangiectasia and Niemann Pick disease type C. So, this study was carried out to analyse the histogenesis of human fetal cerebellar cortex. Methods: The study was conducted in the 30 aborted foetuses. The development of various layers of the cerebellar cortex is studied. All the layers of cerebellum were measured using image analyzer software-image pro premier 9.1. Data analysis was done by regular Statistical method. Results: The thickness of the 3 layers shows a gradual increase that indicates the developmental aspect of the 3 layers of the Embryo. The Purkinje cells appeared during the 4th month of embryonic period. Conclusion: The present study will facilitates in the identification of various pathological lesion of cerebellum which may develop in intrauterine life of fetus.

Keywords

• cerebellum
• purkinje cell
• aborted fetus
• gestational age
• niemann pick disease type c