Nature Communications (Jun 2019)
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
- Luigi Racioppi,
- Erik R. Nelson,
- Wei Huang,
- Debarati Mukherjee,
- Scott A. Lawrence,
- William Lento,
- Anna Maria Masci,
- Yiquin Jiao,
- Sunghee Park,
- Brian York,
- Yaping Liu,
- Amy E. Baek,
- David H. Drewry,
- William J. Zuercher,
- Francesca R. Bertani,
- Luca Businaro,
- Joseph Geradts,
- Allison Hall,
- Anthony R. Means,
- Nelson Chao,
- Ching-yi Chang,
- Donald P. McDonnell
Affiliations
- Luigi Racioppi
- Department of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine
- Erik R. Nelson
- Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
- Wei Huang
- Department of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine
- Debarati Mukherjee
- Department of Pharmacology and Cancer Biology, Duke University School of Medicine
- Scott A. Lawrence
- Department of Pharmacology and Cancer Biology, Duke University School of Medicine
- William Lento
- Department of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine
- Anna Maria Masci
- Department of Biostatistics and Bioinformatics, Duke University
- Yiquin Jiao
- Department of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine
- Sunghee Park
- Department of Pharmacology and Cancer Biology, Duke University School of Medicine
- Brian York
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Yaping Liu
- Department of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine
- Amy E. Baek
- Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
- David H. Drewry
- Department of Chemical Biology, GlaxoSmithKline, Research Triangle Park
- William J. Zuercher
- Department of Chemical Biology, GlaxoSmithKline, Research Triangle Park
- Francesca R. Bertani
- CNR IFN Institute for Photonics and Nanotechnologies
- Luca Businaro
- CNR IFN Institute for Photonics and Nanotechnologies
- Joseph Geradts
- Department of Population Sciences, City of Hope National Medical Center
- Allison Hall
- Department of Pathology, Duke University School of Medicine
- Anthony R. Means
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Nelson Chao
- Department of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine
- Ching-yi Chang
- Department of Pharmacology and Cancer Biology, Duke University School of Medicine
- Donald P. McDonnell
- Department of Pharmacology and Cancer Biology, Duke University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-10424-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is highly expressed in several cancers. Here the authors investigate the role of CaMKK2 expression in the tumour microenvironment and show that CaMKK2 expression in tumour-associated macrophages promotes tumour growth by suppressing T cell anti-tumour activity.
