Annotation of chromatin states in 66 complete mouse epigenomes during development

Abstract

van der Velde et al. present a resource for understanding changes in chromatin states during mouse prenatal development. The authors annotate ATAC-seq, whole-genome bisulfite sequencing, and ChIP-seq of data from Phase III of the ENCODE Project and find that bivalent regions are especially important for silencing lineage-specific genes, including master transcription factors.