Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma

Takahiro Tsuji; Young Hak Kim; Hiroaki Ozasa; Yuichi Sakamori; Hiroki Nagai; Hitomi Ajimizu; Yoshitaka Yagi; Atsuyuki Furukawa; Hironori Haga; Michiaki Mishima

doi:10.1016/j.rmcr.2015.05.003

Respiratory Medicine Case Reports (Jan 2015)

Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma

Takahiro Tsuji,
Young Hak Kim,
Hiroaki Ozasa,
Yuichi Sakamori,
Hiroki Nagai,
Hitomi Ajimizu,
Yoshitaka Yagi,
Atsuyuki Furukawa,
Hironori Haga,
Michiaki Mishima

Affiliations

Takahiro Tsuji: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
Young Hak Kim: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
Hiroaki Ozasa: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
Yuichi Sakamori: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
Hiroki Nagai: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
Hitomi Ajimizu: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
Yoshitaka Yagi: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
Atsuyuki Furukawa: Department of Diagnostic Pathology, Kyoto University Hospital, Japan
Hironori Haga: Department of Diagnostic Pathology, Kyoto University Hospital, Japan
Michiaki Mishima: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan

DOI: https://doi.org/10.1016/j.rmcr.2015.05.003
Journal volume & issue: Vol. 15, no. C
pp. 48 – 50

Abstract

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Introduction: Pulmonary spindle cell carcinoma (SpCC) is a rare subtype of non-small-cell lung cancer (NSCLC) and, in general, is chemoresistance. Case: A sixty-five year-old male patient with metastatic pulmonary SpCC was initially treated with cisplatin and docetaxel, but his disease progressed. Then, he received a combination chemotherapy with carboplatin and nab-PTX followed by maintenanced chemotherapy with nab-PTX. Fluorodeoxyglucose (FDG) positron-emission CT revealed a substantial decrease of FDG accumulation in the primary tumor, and the response continued for more than 7 months. Discussion: Preclinical models suggested that nab-PTX may reach the tumor microenvironment more efficiently than solvent-based paclitaxel (sb-PTX) and be preferentially taken up by cancer cells. Considering that there is no effective treatment for patients with pulmonary SpCC, nab-PTX may merit further investigation in patients with pulmonary SpCC.

Published in Respiratory Medicine Case Reports

ISSN: 2213-0071 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://www.journals.elsevier.com/respiratory-medicine-case-reports/

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