Nature Communications (Aug 2021)

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

  • Geraldine Nouailles,
  • Emanuel Wyler,
  • Peter Pennitz,
  • Dylan Postmus,
  • Daria Vladimirova,
  • Julia Kazmierski,
  • Fabian Pott,
  • Kristina Dietert,
  • Michael Muelleder,
  • Vadim Farztdinov,
  • Benedikt Obermayer,
  • Sandra-Maria Wienhold,
  • Sandro Andreotti,
  • Thomas Hoefler,
  • Birgit Sawitzki,
  • Christian Drosten,
  • Leif E. Sander,
  • Norbert Suttorp,
  • Markus Ralser,
  • Dieter Beule,
  • Achim D. Gruber,
  • Christine Goffinet,
  • Markus Landthaler,
  • Jakob Trimpert,
  • Martin Witzenrath

DOI
https://doi.org/10.1038/s41467-021-25030-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

The immune response is key in determining disease severity of COVID19. Here Nouailles et al., apply bulk proteomics and scRNA-Seq of lung and blood samples of SARS-CoV-2 infected Syrian hamsters and provide a temporal atlas of the systemic and pulmonary cellular responses.