Nature Communications (Aug 2021)
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
- Geraldine Nouailles,
- Emanuel Wyler,
- Peter Pennitz,
- Dylan Postmus,
- Daria Vladimirova,
- Julia Kazmierski,
- Fabian Pott,
- Kristina Dietert,
- Michael Muelleder,
- Vadim Farztdinov,
- Benedikt Obermayer,
- Sandra-Maria Wienhold,
- Sandro Andreotti,
- Thomas Hoefler,
- Birgit Sawitzki,
- Christian Drosten,
- Leif E. Sander,
- Norbert Suttorp,
- Markus Ralser,
- Dieter Beule,
- Achim D. Gruber,
- Christine Goffinet,
- Markus Landthaler,
- Jakob Trimpert,
- Martin Witzenrath
Affiliations
- Geraldine Nouailles
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Division of Pulmonary Inflammation
- Emanuel Wyler
- Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Peter Pennitz
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Division of Pulmonary Inflammation
- Dylan Postmus
- Berlin Institute of Health (BIH)
- Daria Vladimirova
- Institute of Virology, Freie Universität Berlin
- Julia Kazmierski
- Berlin Institute of Health (BIH)
- Fabian Pott
- Berlin Institute of Health (BIH)
- Kristina Dietert
- Institute of Veterinary Pathology, Freie Universität Berlin
- Michael Muelleder
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Core Facility – High-Throughput Mass Spectrometry
- Vadim Farztdinov
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Core Facility – High-Throughput Mass Spectrometry
- Benedikt Obermayer
- Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Core Unit Bioinformatics
- Sandra-Maria Wienhold
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Division of Pulmonary Inflammation
- Sandro Andreotti
- Bioinformatics Solution Center, Freie Universität Berlin
- Thomas Hoefler
- Institute of Virology, Freie Universität Berlin
- Birgit Sawitzki
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Immunology
- Christian Drosten
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Virology
- Leif E. Sander
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine
- Norbert Suttorp
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine
- Markus Ralser
- The Francis Crick Institute, Molecular Biology of Metabolism Laboratory
- Dieter Beule
- Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Core Unit Bioinformatics
- Achim D. Gruber
- Institute of Veterinary Pathology, Freie Universität Berlin
- Christine Goffinet
- Berlin Institute of Health (BIH)
- Markus Landthaler
- Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Jakob Trimpert
- Institute of Virology, Freie Universität Berlin
- Martin Witzenrath
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Division of Pulmonary Inflammation
- DOI
- https://doi.org/10.1038/s41467-021-25030-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The immune response is key in determining disease severity of COVID19. Here Nouailles et al., apply bulk proteomics and scRNA-Seq of lung and blood samples of SARS-CoV-2 infected Syrian hamsters and provide a temporal atlas of the systemic and pulmonary cellular responses.
