Immuno-Molecular Targeted Therapy Use and Survival Benefit in Patients with Stage IVB Cervical Carcinoma in Commission on Cancer<sup>®</sup>-Accredited Facilities in the United States

Collin A. Sitler; Chunqiao Tian; Chad A. Hamilton; Michael T. Richardson; John K. Chan; Daniel S. Kapp; Charles A. Leath; Yovanni Casablanca; Christina Washington; Nicole P. Chappell; Ann H. Klopp; Craig D. Shriver; Christopher M. Tarney; Nicholas W. Bateman; Thomas P. Conrads; George Larry Maxwell; Neil T. Phippen; Kathleen M. Darcy

doi:10.3390/cancers16051071

Cancers (Mar 2024)

Immuno-Molecular Targeted Therapy Use and Survival Benefit in Patients with Stage IVB Cervical Carcinoma in Commission on Cancer<sup>®</sup>-Accredited Facilities in the United States

Collin A. Sitler,
Chunqiao Tian,
Chad A. Hamilton,
Michael T. Richardson,
John K. Chan,
Daniel S. Kapp,
Charles A. Leath,
Yovanni Casablanca,
Christina Washington,
Nicole P. Chappell,
Ann H. Klopp,
Craig D. Shriver,
Christopher M. Tarney,
Nicholas W. Bateman,
Thomas P. Conrads,
George Larry Maxwell,
Neil T. Phippen,
Kathleen M. Darcy

Affiliations

Collin A. Sitler: Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
Chunqiao Tian: Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
Chad A. Hamilton: Gynecologic Oncology Section, Women’s Services and The Ochsner Cancer Institute, Ochsner Health, New Orleans, LA 70115, USA
Michael T. Richardson: Department of Obstetrics and Gynecology, Los Angeles School of Medicine, University of California, Los Angeles, CA 90024, USA
John K. Chan: Palo Alto Medical Foundation, California Pacific Medical Center, Sutter Health, San Francisco, CA 94010, USA
Daniel S. Kapp: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Charles A. Leath: Division of Gynecologic Oncology, University of Alabama at Birmingham, O’Neal Comprehensive Cancer Center, Birmingham, AL 35249, USA
Yovanni Casablanca: Gynecologic Oncology Division, Levine Cancer Institute, Atrium Health, Charlotte, NC 28204, USA
Christina Washington: Gynecologic Oncology Division, Stephenson Cancer Center, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA
Nicole P. Chappell: Gynecologic Oncology Division, GW Medical Faculty Associates, George Washington University, Washington, DC 20037, USA
Ann H. Klopp: Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Craig D. Shriver: Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
Christopher M. Tarney: Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
Nicholas W. Bateman: Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
Thomas P. Conrads: Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
George Larry Maxwell: Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
Neil T. Phippen: Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
Kathleen M. Darcy: Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA

DOI: https://doi.org/10.3390/cancers16051071
Journal volume & issue: Vol. 16, no. 5
p. 1071

Abstract

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Purpose: To investigate IMT use and survival in real-world stage IVB cervical cancer patients outside randomized clinical trials. Methods: Patients diagnosed with stage IVB cervical cancer during 2013–2019 in the National Cancer Database and treated with chemotherapy (CT) ± external beam radiation (EBRT) ± intracavitary brachytherapy (ICBT) ± IMT were studied. The adjusted hazard ratio (AHR) and 95% confidence interval (CI) for risk of death were estimated in patients treated with vs. without IMT after applying propensity score analysis to balance the clinical covariates. Results: There were 3164 evaluable patients, including 969 (31%) who were treated with IMT. The use of IMT increased from 11% in 2013 to 46% in 2019. Age, insurance, facility type, sites of distant metastasis, and type of first-line treatment were independently associated with using IMT. In propensity-score-balanced patients, the median survival was 18.6 vs. 13.1 months for with vs. without IMT (p < 0.001). The AHR was 0.72 (95% CI = 0.64–0.80) for adding IMT overall, 0.72 for IMT + CT, 0.66 for IMT + CT + EBRT, and 0.69 for IMT + CT + EBRT + ICBT. IMT-associated survival improvements were suggested in all subgroups by age, race/ethnicity, comorbidity score, facility type, tumor grade, tumor size, and site of metastasis. Conclusions: IMT was associated with a consistent survival benefit in real-world patients with stage IVB cervical cancer.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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