Osteosarcomatous Transformation in Mazabraud Syndrome: A Case Report

Abstract

Mazabraud syndrome is a rare benign disease that is accompanied by polyostotic fibrous dysplasia and intramuscular myxoma. Malignant transformation of fibrous dysplasia occurs in approximately 1% of cases. To date, only eight cases of malignant transformation, of fibrous dysplasia to osteosarcoma, in Mazabraud syndrome have been reported worldwide. The authors report the first case of osteosarcomatous transformation in a patient with Mazabraud syndrome in the Republic of Korea, focusing on imaging findings.

Keywords

• mazabraud syndrome
• transformation
• neoplastic cell
• fibrous dysplasia of bone
• myxoma; osteosarcoma
• magnetic resonance