C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

Antoine Dufour; Caroline L. Bellac; Ulrich Eckhard; Nestor Solis; Theo Klein; Reinhild Kappelhoff; Nikolaus Fortelny; Parker Jobin; Jacob Rozmus; Jennifer Mark; Paul Pavlidis; Vincent Dive; Sean J. Barbour; Christopher M. Overall

doi:10.1038/s41467-018-04717-4

Nature Communications (Jun 2018)

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

Antoine Dufour,
Caroline L. Bellac,
Ulrich Eckhard,
Nestor Solis,
Theo Klein,
Reinhild Kappelhoff,
Nikolaus Fortelny,
Parker Jobin,
Jacob Rozmus,
Jennifer Mark,
Paul Pavlidis,
Vincent Dive,
Sean J. Barbour,
Christopher M. Overall

Affiliations

Antoine Dufour: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Caroline L. Bellac: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Ulrich Eckhard: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Nestor Solis: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Theo Klein: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Reinhild Kappelhoff: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Nikolaus Fortelny: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Parker Jobin: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Jacob Rozmus: Department of Pediatrics, Child and Family Research Institute and BC Children’s Hospital, University of British Columbia
Jennifer Mark: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia
Paul Pavlidis: Centre for High Throughput Biology, University of British Columbia
Vincent Dive: Commissariat a l’Energie Atomique (CEA) CE-Saclay, Labex LERMIT, Service d’Ingenierie Moleculaire des Proteines
Sean J. Barbour: Department of Medicine, University of British Columbia
Christopher M. Overall: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia

DOI: https://doi.org/10.1038/s41467-018-04717-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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IFN-γ is central in inflammatory pathogenesis, response to infection and autoimmune diseases. Here the authors show that MMP12 expression is reduced in patients with SLE and that MMP12 post-translationally truncates IFN-y, inhibiting its function and affecting pathogenesis of mouse models of peritonitis, SLE and rheumatoid arthritis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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