New approaches to verapamil and ketamine use in brain gliomas treatment

Abstract

Introduction. A new experimental approach to channel blockers verapamil and ketamine use in treatment of malignant brain gliomas was elaborated on highly invasive and malignant rat glioma strain 101.8 taking into consideration influence of pathogenic mechanism on ionotropic NMDA-receptors mediated through blood cells aggregation.Materials and methods. Effects of verapamil and ketamine in different dilutions (10-1-10-6) on blood cells aggregation were studied in 312 patients with neurosurgical diseases and 15 Wistar rats. Experimental testing of the method was performed in 70 rats, which received drugs in concentrations that maximally reduced blood cells aggregation as in patients with glioblastoma and rats with glioma 101.8, in order to inhibit it’s growth.Results. Channel blockers administration in concentrations that optimally decreased blood cells aggregation in patients with glioblastoma and experimental animals, most effectively inhibited glioma’s 101.8 growth in rats.Conclusions. It has been experimentally proved that use of verapamil and ketamine in low concentrations effectively decreased blood cells aggregation in patients with neurosurgical diseases through inhibition of activity of ionotropic NMDA-receptors. New approaches of verapamil and ketamine use for antitumor effect at brain glioma through NMDA-receptors channel blocking were elaborated.