Nature Communications (2021-03-01)

Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors

  • Karsten Bach,
  • Sara Pensa,
  • Marija Zarocsinceva,
  • Katarzyna Kania,
  • Julie Stockis,
  • Silvain Pinaud,
  • Kyren A. Lazarus,
  • Mona Shehata,
  • Bruno M. Simões,
  • Alice R. Greenhalgh,
  • Sacha J. Howell,
  • Robert B. Clarke,
  • Carlos Caldas,
  • Timotheus Y. F. Halim,
  • John C. Marioni,
  • Walid T. Khaled

Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11


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BRCA1 driven breast cancer arises from luminal progenitor cells but how BRCA1 loss-of-function affects the luminal progenitor cell state during premalignant stages of the disease is still unclear. Here, the authors demonstrate an aberrant differentiation of luminal progenitors towards a partial secretory luminal cell phenotype that occurs in a Brca1 deficient mouse model of breast cancer at early stages of tumour initiation and in breast cells from BRCA1 carriers.