The effect of corvitin on the indicators of the nitric oxide system in the kidneys under the conditions of the development of experimental pneumonia and adrenaline damage to the myocardium

Abstract

Currently, the effect of corvitin on the indicators of the nitric oxide system in the kidneys in experimental pneumonia (EP) and adrenaline damage to the myocardium (APM) is not studied. The aim of our study was to find out the effect of the corvitin drug on the disturbed markers of the nitric oxide system in the kidneys in EP and APM. The EP was reproduced according to the method of V.N. Shlyapnikov. by infecting animals with staphylococcus. APM was modeled by a single intravenous injection of an adrenaline solution. The scientific work revealed an increase in the content of stable metabolites of nitric oxide and total NOS activity against the background of a decrease in the level of L-arginine in the kidneys in EP and APM, which dominated on the 14th day of comorbid pathology versus control. The use of corvitin caused a corrective effect on the disturbed markers of the nitric oxide system in the kidneys in EP and APM.

Keywords

• experimental pneumonia
• adrenaline damage to the myocardium
• corvitin
• nitric oxide system