Non-coding RNA-Mediated N6-Methyladenosine (m6A) deposition: A pivotal regulator of cancer, impacting key signaling pathways in carcinogenesis and therapy response

Mehrdad Hashemi; Pouria Daneii; Mohammad Arad Zandieh; Rasoul Raesi; Neda Zahmatkesh; Mehrsa Bayat; Anwar Abuelrub; Zeinab Khazaei Koohpar; Amir Reza Aref; Ali Zarrabi; Mohsen Rashidi; Shokooh Salimimoghadam; Maliheh Entezari; Afshin Taheriazam; Ramin Khorrami

Non-coding RNA Research (Mar 2024)

Non-coding RNA-Mediated N6-Methyladenosine (m6A) deposition: A pivotal regulator of cancer, impacting key signaling pathways in carcinogenesis and therapy response

Mehrdad Hashemi,
Pouria Daneii,
Mohammad Arad Zandieh,
Rasoul Raesi,
Neda Zahmatkesh,
Mehrsa Bayat,
Anwar Abuelrub,
Zeinab Khazaei Koohpar,
Amir Reza Aref,
Ali Zarrabi,
Mohsen Rashidi,
Shokooh Salimimoghadam,
Maliheh Entezari,
Afshin Taheriazam,
Ramin Khorrami

Affiliations

Mehrdad Hashemi: Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Pouria Daneii: Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Mohammad Arad Zandieh: Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Rasoul Raesi: Department of Health Services Management, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical-Surgical Nursing, Mashhad University of Medical Sciences, Mashhad, Iran
Neda Zahmatkesh: Department of Genetics, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Mehrsa Bayat: Department of Health Sciences, Bahcesehir University, Istanbul, Turkey
Anwar Abuelrub: Neuroscience Laboratory, Health Sciences Institute, Bahcesehir University, Istanbul, Turkey
Zeinab Khazaei Koohpar: Department of Cell and Molecular Biology, Faculty of Biological Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Amir Reza Aref: Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Ali Zarrabi: Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, 34396, Turkey
Mohsen Rashidi: Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Corresponding author. Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Shokooh Salimimoghadam: Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran; Corresponding author.
Maliheh Entezari: Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding author. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Afshin Taheriazam: Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding author. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Ramin Khorrami: Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Corresponding author.

Journal volume & issue: Vol. 9, no. 1
pp. 84 – 104

Abstract

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The emergence of RNA modifications has recently been considered as critical post-transcriptional regulations which governed gene expression. N6-methyladenosine (m6A) modification is the most abundant type of RNA modification which is mediated by three distinct classes of proteins called m6A writers, readers, and erasers. Accumulating evidence has been made in understanding the role of m6A modification of non-coding RNAs (ncRNAs) in cancer. Importantly, aberrant expression of ncRNAs and m6A regulators has been elucidated in various cancers. As the key role of ncRNAs in regulation of cancer hallmarks is well accepted now, it could be accepted that m6A modification of ncRNAs could affect cancer progression. The present review intended to discuss the latest knowledge and importance of m6A epigenetic regulation of ncRNAs including mircoRNAs, long non-coding RNAs, and circular RNAs, and their interaction in the context of cancer. Moreover, the current insight into the underlying mechanisms of therapy resistance and also immune response and escape mediated by m6A regulators and ncRNAs are discussed.

Published in Non-coding RNA Research

ISSN: 2468-0540 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/non-coding-rna-research/

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