Salivary and serum neopterin and interleukin 6 as biomarkers in patients with oral and oropharyngeal squamous cell carcinoma
Saskova Lenka,
Tvrdy Peter,
Melichar Bohuslav,
Pink Richard,
Kral David,
Michl Petr,
Dvorak Zdenek
Affiliations
Saskova Lenka
Department of Oral and Maxillofacial Surgery, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, I.P. Pavlova 6, 779 00, Olomouc, Czech Republic
Tvrdy Peter
Department of Oral and Maxillofacial Surgery, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, I.P. Pavlova 6, 779 00, Olomouc, Czech Republic
Melichar Bohuslav
Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic
Pink Richard
Department of Oral and Maxillofacial Surgery, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, I.P. Pavlova 6, 779 00, Olomouc, Czech Republic
Kral David
Department of Oral and Maxillofacial Surgery, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, I.P. Pavlova 6, 779 00, Olomouc, Czech Republic
Michl Petr
Department of Oral and Maxillofacial Surgery, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, I.P. Pavlova 6, 779 00, Olomouc, Czech Republic
Dvorak Zdenek
Department of Plastic and Aesthetic Surgery, St. Anne’s University Hospital, Brno, Czech Republic
Because of an increasing incidence of malignant tumours of the head and neck there is an unmet medical need for early diagnosis of the primary disease or precancerous lesions, and timely detection of recurrence by simple non-invasive tests. The analysis of biomarkers in body fluids may be appropriate for this goal. In this review, we compare the data on utilization of neopterin and interleukin-6 (IL-6) measurements in saliva and plasma/serum of patients with oral and oropharyngeal squamous cell carcinoma, indicating the suitability of using saliva as a diagnostic matrix in head and neck cancers on behalf of close anatomical proximity and a potential to study the tumour microenvironment. Salivary neopterin and IL-6 are potential biomarkers of head and neck cancer suitable not only for early diagnosis, but also for monitoring of treatment results and detection of the disease recurrence.
