Cancers (Jan 2023)

Discovering the Clinical and Prognostic Role of Pan-Immune-Inflammation Values on Oral Cavity Squamous Cell Carcinoma

  • Chia-Chi Yeh,
  • Huang-Kai Kao,
  • Yenlin Huang,
  • Tsung-You Tsai,
  • Chi-Kuang Young,
  • Shao-Yu Hung,
  • Chuieng-Yi Lu,
  • Kai-Ping Chang

DOI
https://doi.org/10.3390/cancers15010322
Journal volume & issue
Vol. 15, no. 1
p. 322

Abstract

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A newly introduced pan-immune-inflammation value (PIV) was not evaluated for its role in oral cavity squamous cell carcinoma (OSCC). In this study, the PIV was calculated with the following equation (neutrophil count × platelet count × monocyte count)/lymphocyte count from the results of the automated hematology analyzers in 853 OSCC patients from 2005 to 2017. The optimal cutoff for the preoperative PIV was 268, as determined by a receiver operating characteristic curve. Significant differences were observed for alcohol consumption, smoking, pT status, pN status, overall pathological status, extranodal extension, cell differentiation, depth of invasion, and perineural invasion between higher and lower PIV patients (all p values p values p = 0.027, HR: 1.281 and p = 0.031, HR: 1.274, respectively). In conclusion, a higher PIV level was associated with poor clinicopathological factors in OSCC patients and could be used to predict poor posttreatment outcomes, especially for overall and distant metastasis-free survival.

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