One pot three components solvent free synthesis of 4-substituted phenyl-2-(sulfanyl/oxo) pyrimidine-5-carboxylate derivatives

Sourav Handique; Priyanka Sharma

Results in Chemistry (Jan 2022)

One pot three components solvent free synthesis of 4-substituted phenyl-2-(sulfanyl/oxo) pyrimidine-5-carboxylate derivatives

Sourav Handique,
Priyanka Sharma

Affiliations

Sourav Handique: Chemistry Laboratory, School of Engineering and Sciences (SoES), G D Goenka University, 122001 Gurugram, Haryana, India
Priyanka Sharma: Corresponding author.; Chemistry Laboratory, School of Engineering and Sciences (SoES), G D Goenka University, 122001 Gurugram, Haryana, India

Journal volume & issue: Vol. 4
p. 100411

Abstract

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An efficient and simple procedure for synthesis of 3,4-dihydropyrimidinone or 3,4-thioxopyrimidinone maintaining eco-friendly protocol by introducing acetic acid as an organo-catalyst in presence of molecular sieves as water absorbent is disclosed. This new approach includes solvent free condition, short reaction duration, and easy isolation with high yield over classical Biginelli reaction..

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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