IMMUNOHISTOCHEMICAL EXPRESSION OF NGF/TrkA AND BDNF/TrkB IN TUMOR PARIENCHYMA AND PERIPROSTATIC ADIPOSE TISSUE, DEPENDING ON THE PATHOANATOMIC STAGE OF PROSTATE CANCER

Abstract

Introduction: For more than 30 years, the idea of inhibiting growth factors has taken over the minds of different generations of scientists since the progression of the neoplastic process is determined by uncontrolled proliferation differentiation and apotosis and the metastasis of the neoangiogenesis process. The aim: of this work is to show the density of immunohistochemical expression of NGF/TrkA and BDNF/TrkB A Trk B in tumor parienchyma and periprostatic adipose tissue. The study ability is to use it as a prognostic indicator for metastasis of prostate cancer. Material and methods: During the period 2018-2022, 184 patients were diagnosed with radical prostateectomy on the occasion of localized prostate cancer with PSA 20 nmoll/ml, Gleason7, GII. study of the density of expression besch determined by a semi-quantitative method and was established by counting epithelial cells associated with a monocronal antibody, calculated on 20 fields. Results: The study showed expression of Trk receptors in epithelial cells in all tissue samples. NGF/TrkA has poor expression in adipose tissue in areas perirectally and ventrally in the pathoanatomical stage G1, and it becomes moderately positive as the process of undifferentiation progresses. The same tendency is observed in the expression of neurotrophin in prostate-epithelial cells. Conclusions: The increased density of NGF, as well as the preoperative determination of the expression of BDNF and TrK a,b receptors in the pathoantomic preparation, can be used as a negative prognostic indicator of the aggressiveness of the CaP tumor, as well as its possible metastasis.

Keywords

• pathogenesis of prostate cancer
• immunohistochemistry
• growth factors
• ngf
• bdnf