Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma
Léa Da Silva,
Timothée Klopfenstein,
Vincent Gendrin,
Julien Clouet,
Lynda Toko,
Quentin Richier,
Thomas Leriche,
Raoul Nicolas,
Alexis Queijo,
Nour Sreiri,
Karine Lacombe,
Souheil Zayet
Affiliations
Léa Da Silva
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
Timothée Klopfenstein
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
Vincent Gendrin
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
Julien Clouet
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
Lynda Toko
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
Quentin Richier
Infectious Diseases Department, Assistance Publique Hopitaux de Paris, Saint-Antoine Hospital, 75012 Paris, France
Thomas Leriche
Rheumatology Department, Nord Franche-Comte Hospital, 90400 Trevenans, France
Raoul Nicolas
Pneumologie Department, Nord Franche-Comte Hospital, 90400 Trevenans, France
Alexis Queijo
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
Nour Sreiri
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
Karine Lacombe
Infectious Diseases Department, Assistance Publique Hopitaux de Paris, Saint-Antoine Hospital, 75012 Paris, France
Souheil Zayet
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
We highlighted in this current paper similar prolonged respiratory presentation with COVID-19 pneumonia in four severely immunocompromised patients currently being treated with anti-CD20 monoclonal antibodies (mAbs), such as ocrelizumab and rituximab, for multiple sclerosis or rheumatoid polyarthritis. Real-time reverse transcription-polymerase chain reaction on a nasopharyngeal swab specimen was negative in all patients. SARS-CoV-2 infection was confirmed from bronchoalveolar lavage fluid. A high titer of post-vaccine COVID-19 convalescent plasma was administered with complete recovery in all patients.
