Nature and Science of Sleep (Sep 2021)
Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report
Abstract
Geoffroy Vellieux,1,2 Justine Frija-Masson,1,2 Anny Rouvel-Tallec,1,2 Xavier Drouot,3 Marie-Pia d’Ortho1,2 1Université de Paris, NeuroDiderot, Inserm, Paris, F-75019, France; 2Centre du sommeil, Service de Physiologie – Explorations Fonctionnelles, AP-HP, Hôpital Bichat-Claude Bernard, Paris, F-75018, France; 3Neurophysiologie Clinique et Explorations Fonctionnelles, CHU de Poitiers, Poitiers, FranceCorrespondence: Geoffroy VellieuxUniversité de Paris, NeuroDiderot, Inserm, Paris, F-75019, FranceTel +33 140258401Fax +33 140257181Email [email protected]: We describe the case of a male patient who was diagnosed with narcolepsy type 1 on the basis of sleep and wake symptoms, and the results of investigations including video-polysomnography, multiple sleep latency test, human leukocyte antigen status and orexin level in cerebrospinal fluid. During the first years after disease onset, the patient did not show any significant improvement despite treatment with a variety of stimulant and anti-cataplectic drugs. However, spontaneous remission of disease occurred after 15 years.Keywords: narcolepsy, cataplexy, excessive daytime sleepiness, orexin, hypocretin, remission
