mBio (Jun 2021)
Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection
- Ariadna Fernández-Calvet,
- Begoña Euba,
- Celia Gil-Campillo,
- Arancha Catalan-Moreno,
- Javier Moleres,
- Sara Martí,
- Alexandra Merlos,
- Jeroen D. Langereis,
- Francisco García-del Portillo,
- Lauren O. Bakaletz,
- Garth D. Ehrlich,
- Eric A. Porsch,
- Margarita Menéndez,
- Joshua C. Mell,
- Alejandro Toledo-Arana,
- Junkal Garmendia
Affiliations
- Ariadna Fernández-Calvet
- Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain
- Begoña Euba
- Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain
- Celia Gil-Campillo
- Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain
- Arancha Catalan-Moreno
- Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain
- Javier Moleres
- Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain
- Sara Martí
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
- Alexandra Merlos
- Department of Pathology and Experimental Therapeutics, IDIBELL-University of Barcelona, L’Hospitalet de Llobregat, Barcelona, Spain
- Jeroen D. Langereis
- ORCiD
- Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands
- Francisco García-del Portillo
- ORCiD
- Laboratorio de Patógenos Bacterianos Intracelulares, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain
- Lauren O. Bakaletz
- ORCiD
- Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA
- Garth D. Ehrlich
- Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
- Eric A. Porsch
- Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
- Margarita Menéndez
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
- Joshua C. Mell
- Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
- Alejandro Toledo-Arana
- Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain
- Junkal Garmendia
- ORCiD
- Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain
- DOI
- https://doi.org/10.1128/mBio.00789-21
- Journal volume & issue
-
Vol. 12,
no. 3
Abstract
Human-adapted bacterial pathogens have evolved specific mechanisms to colonize their host niche. Phase variation is a contingency strategy to allow adaptation to changing conditions, as phase-variable bacterial loci rapidly and reversibly switch their expression.
