Nature Communications (Sep 2016)
A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
Abstract
Immune system participates in the development of high blood pressure. Here the authors show that cholinergic-sympathetic pathway mediated by the α7nAChR receptor and the activation of splenic T cells prime immunity during hypertension and that selective splenic denervation protects against the onset of hypertension in mice.