Nature Communications (Sep 2016)

A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

  • Daniela Carnevale,
  • Marialuisa Perrotta,
  • Fabio Pallante,
  • Valentina Fardella,
  • Roberta Iacobucci,
  • Stefania Fardella,
  • Lorenzo Carnevale,
  • Raimondo Carnevale,
  • Massimiliano De Lucia,
  • Giuseppe Cifelli,
  • Giuseppe Lembo

DOI
https://doi.org/10.1038/ncomms13035
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Immune system participates in the development of high blood pressure. Here the authors show that cholinergic-sympathetic pathway mediated by the α7nAChR receptor and the activation of splenic T cells prime immunity during hypertension and that selective splenic denervation protects against the onset of hypertension in mice.