Sanwei sandalwood decoction ameliorates acute ischemiareperfusion injury in rats by modulating myocyte electrophysiological characteristics

Quan Wan; Yu Wang; Ming Yong; PengFei Hu; Che Ge Le Liang; Xiang Jun Yang; Xiao Zhao; Dan San; Ting Ting Bai; La Ga Tong; Jingbo Zhai; Ming Zhao; QingShan Zhang

Biomedicine & Pharmacotherapy (Feb 2023)

Sanwei sandalwood decoction ameliorates acute ischemiareperfusion injury in rats by modulating myocyte electrophysiological characteristics

Quan Wan,
Yu Wang,
Ming Yong,
PengFei Hu,
Che Ge Le Liang,
Xiang Jun Yang,
Xiao Zhao,
Dan San,
Ting Ting Bai,
La Ga Tong,
Jingbo Zhai,
Ming Zhao,
QingShan Zhang

Affiliations

Quan Wan: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
Yu Wang: Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
Ming Yong: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
PengFei Hu: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
Che Ge Le Liang: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
Xiang Jun Yang: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
Xiao Zhao: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
Dan San: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
Ting Ting Bai: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
La Ga Tong: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University
Jingbo Zhai: Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Tongliao 028000, PR China
Ming Zhao: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University; Correspondence to: 1472 Holin He Street, Tongliao City, Inner Mongolia 028002, PR China.
QingShan Zhang: Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University; Correspondence to: 1472 Holin He Street, Tongliao City, Inner Mongolia 028002, PR China.

Journal volume & issue: Vol. 158
p. 114103

Abstract

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Sanwei sandalwood decoction (SWTX) is a classical Chinese medicine formula and clinically effective treatment for coronary heart disease, including myocardial ischemia/reperfusion (I/R) injury. Because the treatment mechanism of SWTX in I/R injury remains obscure, we intended to analyze the potential cardioprotective effects of SWTX in rats with myocardial I/R injury. Our research revealed that SWTX prolonged ventricular conduction time in a dose-dependent manner. While SWTX significantly delayed left ventricular signal conduction velocity, it had no effect on left atrial conduction velocity. Under sinus conditions, low SWTX concentrations reduced left ventricular conduction dispersion, while high concentrations increased conduction dispersion. SWTX also prolonged the QRS interval, APD30/50/90, and ERP. In whole-cell patch clamp experiments on myocytes, Ito and Ikr were inhibited by SWTX. While SWTX had no effect on INa, the activation curve for Nav1.5 was left-shifted. Finally, SWTX reduced the probability of ventricular fibrillation and suppressed early and late depolarization in an acute I/R injury rat model. These findings shed light on the mechanism by which SWTX alleviates myocardial I/R injury.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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