Materials (Aug 2016)

Fabrication and Physical Evaluation of Gelatin-Coated Carbonate Apatite Foam

  • Kanae Hara,
  • Kenji Fujisawa,
  • Hirokazu Nagai,
  • Natsumi Takamaru,
  • Go Ohe,
  • Kanji Tsuru,
  • Kunio Ishikawa,
  • Youji Miyamoto

DOI
https://doi.org/10.3390/ma9090711
Journal volume & issue
Vol. 9, no. 9
p. 711

Abstract

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Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin; however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.

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