Synthesis and Structural Characterization of Half-Sandwich Arene–Ruthenium(II) Complexes with Bis(imidazol-1-yl)methane, Imidazole and Benzimidazole
Vladislava V. Matveevskaya,
Dmitry I. Pavlov,
Denis G. Samsonenko,
Ekaterina A. Ermakova,
Lyubov S. Klyushova,
Sergey V. Baykov,
Vadim P. Boyarskiy,
Andrei S. Potapov
Affiliations
Vladislava V. Matveevskaya
Nikolaev Institute of Inorganic Chemistry, 3 Lavrentiev Ave., 630090 Novosibirsk, Russia
Dmitry I. Pavlov
Nikolaev Institute of Inorganic Chemistry, 3 Lavrentiev Ave., 630090 Novosibirsk, Russia
Denis G. Samsonenko
Nikolaev Institute of Inorganic Chemistry, 3 Lavrentiev Ave., 630090 Novosibirsk, Russia
Ekaterina A. Ermakova
Institute of Molecular Biology and Biophysics—Subdivision of Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, Russia
Lyubov S. Klyushova
Institute of Molecular Biology and Biophysics—Subdivision of Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, Russia
Sergey V. Baykov
Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, 198504 Peterhof, Russia
Vadim P. Boyarskiy
Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, 198504 Peterhof, Russia
Andrei S. Potapov
Nikolaev Institute of Inorganic Chemistry, 3 Lavrentiev Ave., 630090 Novosibirsk, Russia
Mono- and binuclear arene–ruthenium(II) complexes with imidazole-containing ligands were prepared by the reaction of the ligands (L1 = bis(imidazole-1-yl)methane; ImH = 1H-Imidazole; BImH = 1H-Benzimidazole) with [(p-cym)Ru(µ-Cl)2]2 dimers. When bis(imidazole-1-yl)methane reacted with [(p-cym)Ru(µ-Cl)2]2 in methanol, a binuclear complex of the type [Ru2(L1)2(p-cym)2Cl2]Cl2 (2) with cyclic structure was synthesized, whereas by using acetonitrile as a solvent under the same reaction conditions, an unexpected C–N bond cleavage was observed, and a complex of formula [Ru(ImH)2(p-cym)Cl]Cl (1) with coordinated imidazole molecules was obtained. Another type of arene–ruthenium complex [Ru(BImH)(p-cym)Cl2] (3) was obtained by the reaction of benzimidazole and [(p-cym)Ru(µ-Cl)2]2. All compounds were characterized by spectral (FT-IR, NMR 1H, 13C) and single-crystal X-ray diffraction methods; their catalytic activity in transfer hydrogenation and the cytotoxicity against MCF-7 and HepG2 cells were evaluated.
