Cardio-Oncology (Nov 2024)
Clinical and pathological characteristics of immune checkpoint inhibitor-related fulminant myocarditis
- Ryo Izumi,
- Toru Hashimoto,
- Hiroshi Kisanuki,
- Kei Ikuta,
- Wataru Otsuru,
- Soshun Asakawa,
- Shoei Yamamoto,
- Kayo Misumi,
- Takeo Fujino,
- Keisuke Shinohara,
- Shouji Matsushima,
- Kazuya Hosokawa,
- Shunsuke Katsuki,
- Taro Mori,
- Mikiko Hashisako,
- Yuki Tateishi,
- Takeshi Iwasaki,
- Yoshinao Oda,
- Shintaro Kinugawa,
- Kohtaro Abe
Affiliations
- Ryo Izumi
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Toru Hashimoto
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Hiroshi Kisanuki
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Kei Ikuta
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Wataru Otsuru
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Soshun Asakawa
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Shoei Yamamoto
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Kayo Misumi
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Takeo Fujino
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Keisuke Shinohara
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Shouji Matsushima
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Kazuya Hosokawa
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Shunsuke Katsuki
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Taro Mori
- Department of Anatomic Pathology, Pathological Sciences, Faculty of Medical Sciences, Kyushu University
- Mikiko Hashisako
- Department of Anatomic Pathology, Pathological Sciences, Faculty of Medical Sciences, Kyushu University
- Yuki Tateishi
- Department of Anatomic Pathology, Pathological Sciences, Faculty of Medical Sciences, Kyushu University
- Takeshi Iwasaki
- Department of Anatomic Pathology, Pathological Sciences, Faculty of Medical Sciences, Kyushu University
- Yoshinao Oda
- Department of Anatomic Pathology, Pathological Sciences, Faculty of Medical Sciences, Kyushu University
- Shintaro Kinugawa
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- Kohtaro Abe
- Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University
- DOI
- https://doi.org/10.1186/s40959-024-00288-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 8
Abstract
Abstract The advent of immune checkpoint inhibitors (ICIs) has significantly improved cancer treatment. With the increasing use of ICIs, ICI-related myocarditis has been recognized. However, an evidence-based therapeutic strategy has not been established because of the limited knowledge on ICI-related myocarditis. Here, we present four cases of ICI-related fulminant myocarditis (FM). Three of the four cases resulted in fatal outcomes despite aggressive treatment with mechanical circulatory support and immunosuppressive therapy with corticosteroids. Given the poor prognosis of ICI-FM, the establishment of rapid and adequate therapeutic interventions on the basis of clinical and pathological evaluation is imperative.
Keywords
- Immune checkpoint inhibitors,
- Immune-related adverse events
- Fulminant myocarditis
- Mechanical circulatory support
- Cardiogenic shock
- Ventricular arrhythmia
