OF THE APPLICATION OF THE CYCLOSPORINE GENERICS IN THE PEDIATRIC RHEUMATOLOGY

Abstract

The article presents the findings of the research dedicated to the efficacy, bioavailability and safety of the generic medications and authentic cyclosporine a. it shows that the application of the generic medications leads both to the reduction in the treatment efficacy and development of the severe side effects. It also presents the information on the qualitative and quantitative contents of cyclosporine a generic medications. Neither of the tested medications complied with authentic Sandimmune Neoral in terms of qualitative and quantitative contents. Likewise, neither of the generic medications has the microemulsive form, which provides for the uniform absorption of a medication and its bioavailability. There are also clinical examples of the application experience, regarding cyclosporine a generic medications among the patients with severe systemic rheumatoid arthritis. The application of the generic medications proved to be ineffective and was accompanied by the growth of renal toxicity.Key words: cyclosporine generics, children, juvenile rheumatoid arthritis.