Nature Communications (Apr 2021)

EFA6B regulates a stop signal for collective invasion in breast cancer

  • Racha Fayad,
  • Monserrat Vázquez Rojas,
  • Mariagrazia Partisani,
  • Pascal Finetti,
  • Shiraz Dib,
  • Sophie Abelanet,
  • Virginie Virolle,
  • Anne Farina,
  • Olivier Cabaud,
  • Marc Lopez,
  • Daniel Birnbaum,
  • François Bertucci,
  • Michel Franco,
  • Frédéric Luton

DOI
https://doi.org/10.1038/s41467-021-22522-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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Reduced expression of EFA6B is found in highly metastatic breast cancer subtypes. Here, the authors report that loss of EFA6B promotes collective invasion through activation of the epithelial-to-mesenchymal transition program and CDC42-dependent signalling pathways in breast cancer.