This paper presents a design method for a high-power optical system with multiple channels to achieve high-quality color-mixing and uniform lighting. The high-power optical system consists of a multi-channel reflector and a color-mixing component. The optical systems with different parameters are simulated to analyze the color-mixing performance. Simulation results show that the illumination uniformity of all optical systems is greater than 0.77, and the maximum color difference is 0.014. This optical system can be introduced into applications, such as illumination of machine vision, simulating daylight, smart lighting, and so on.