Nature Communications (Jun 2021)

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors

  • Aimei Fei,
  • Wanqing Wu,
  • Longzhi Tan,
  • Cheng Tang,
  • Zhengrong Xu,
  • Xiaona Huo,
  • Hongqiang Bao,
  • Yalei Kong,
  • Mark Johnson,
  • Griffin Hartmann,
  • Mustafa Talay,
  • Cheng Yang,
  • Clemens Riegler,
  • Kristian J. Herrera,
  • Florian Engert,
  • X. Sunney Xie,
  • Gilad Barnea,
  • Stephen D. Liberles,
  • Hui Yang,
  • Qian Li

DOI
https://doi.org/10.1038/s41467-021-23823-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

In our nose, some neuron subpopulations express a family of trace amine associated receptors (TAARs, smelling e.g., rotten fish). Fei et al. identify two conserved enhancers across placental mammals named TAAR enhancer 1 and 2 that coordinately regulate expression of the entire Taar gene repertoire.