Nature Communications (Aug 2019)
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program
- Jacklyn N. Hellwege,
- Digna R. Velez Edwards,
- Ayush Giri,
- Chengxiang Qiu,
- Jihwan Park,
- Eric S. Torstenson,
- Jacob M. Keaton,
- O. D. Wilson,
- Cassianne Robinson-Cohen,
- Cecilia P. Chung,
- Christianne L. Roumie,
- Derek Klarin,
- Scott M. Damrauer,
- Scott L. DuVall,
- Edward Siew,
- Elvis A. Akwo,
- Matthias Wuttke,
- Mathias Gorski,
- Man Li,
- Yong Li,
- J. Michael Gaziano,
- Peter W. F. Wilson,
- Philip S. Tsao,
- Christopher J. O’Donnell,
- Csaba P. Kovesdy,
- Cristian Pattaro,
- Anna Köttgen,
- Katalin Susztak,
- Todd L. Edwards,
- Adriana M. Hung
Affiliations
- Jacklyn N. Hellwege
- Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University
- Digna R. Velez Edwards
- Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University
- Ayush Giri
- Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University
- Chengxiang Qiu
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Jihwan Park
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Eric S. Torstenson
- Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University
- Jacob M. Keaton
- Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University
- O. D. Wilson
- Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center
- Cassianne Robinson-Cohen
- Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center
- Cecilia P. Chung
- Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University
- Christianne L. Roumie
- Veteran Affairs Administration Tennessee Valley VA Health Care System Geriatric Research Education Clinical Center (GRECC)
- Derek Klarin
- VA Boston Health Care System
- Scott M. Damrauer
- Department of Surgery, Corporal Michael Crescenz VA Medical Center
- Scott L. DuVall
- VA Salt Lake City Health Care System
- Edward Siew
- Department of Medicine, Vanderbilt University Medical Center
- Elvis A. Akwo
- Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center
- Matthias Wuttke
- Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Centre—University of Freiburg
- Mathias Gorski
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Man Li
- VA Boston Health Care System
- Yong Li
- Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Centre—University of Freiburg
- J. Michael Gaziano
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Peter W. F. Wilson
- Atlanta VA Medical Center
- Philip S. Tsao
- VA Palo Alto Health Care System
- Christopher J. O’Donnell
- VA Boston Health Care System
- Csaba P. Kovesdy
- Nephrology Section, Memphis VA Medical Center
- Cristian Pattaro
- Institute for Biomedicine, Eurac Research
- Anna Köttgen
- Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Centre—University of Freiburg
- Katalin Susztak
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Todd L. Edwards
- Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University
- Adriana M. Hung
- Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University
- DOI
- https://doi.org/10.1038/s41467-019-11704-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue and anatomical contexts of renal homeostasis.
